On May 17, 2022, the NRC issued a Notice of Violation to the University of Wyoming (Licensee) for a Severity Level (SL) III problem associated with two (A+B) related violations and an SL IV violation (C). The violations involved the licensee’s: (A) failure to establish adequate administrative controls to assure safe operations involving licensed materials as required by Title 10 of the Code of Federal Regulations (10 CFR) 33.13(c)(3); (B) possession and use of byproduct material in excess of the NRC-authorized possession limits contrary to 10 CFR 30.3(a); and (C) failure to use proper labeling of a container with byproduct material in accordance with 10 CFR 20.1904(a). Specifically, the licensee’s administrative procedures failed to assure: (i) control of procurement and use of byproduct material; (ii) completion of safety evaluations of proposed uses of byproduct material, training and experience of the user, and the operating or handling procedures; and (iii) review, approval, and recording by the radiation safety committee of safety evaluations of proposed uses prior to use of the byproduct material. Further, on November 17, 2021, the licensee possessed an approximately 18.4 millicurie Am-241 metal source that was not authorized by its NRC license and the source was not labelled as required with sufficient information to take precautions to avoid or minimize exposures.